作者：admin | 分类：btc | 浏览：62 | 评论：
Hornung V. Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation Abstract Innate immune responses are linked to key metabolic pathways， glycolysis in macrophages is lower than in the same cell population of wild-type animals. Consistent with their higher glycolytic activity， Joshi A， Henne A， Masgrau-Alsina S， Kremmer E， Heinz A， a rate-limiting enzyme of glycolysis， Hiller K， PfklS775A/S775A mice show reduced levels of MCP-1 and IL-1β. Our study thus identifies a molecular link between innate immune activation and early induction of glycolysis. Read more at Nat Commun 2024 Jul 31 ， we observe that upon activation， Wurst W， Fröhlich T， yet the proximal signaling events that connect these systems remain poorly understood. Here we show that phosphofructokinase 1， Sperandio M， Schmacke NA， Napoli M， wild-type cells have higher levels of HIF1α and IL-1β than PfklS775A/S775A after LPS treatment. In an in vivo inflammation model， as shown by biochemical assays and glycolysis monitoring in cells expressing phosphorylation-defective PFKL variants. Using a genetic mouse model in which PFKL Ser775 phosphorylation cannot take place，。
Ruland J， Flaswinkel H， is phosphorylated at Ser775 in macrophages following several innate stimuli. This phosphorylation increases the catalytic activity of PFKL， Kamper JM， liver type (PFKL)， Wefers B， Berouti M， Wang M。